User profiles for Aleksander Sobczyk
Aleksander SobczykSVP, Two Sigma Investments LP Verified email at twosigma.com Cited by 2479 |
Channelrhodopsin-2–assisted circuit mapping of long-range callosal projections
The functions of cortical areas depend on their inputs and outputs, but the detailed circuits
made by long-range projections are unknown. We show that the light-gated channel …
made by long-range projections are unknown. We show that the light-gated channel …
NMDA receptor subunit-dependent [Ca2+] signaling in individual hippocampal dendritic spines
Ca 2+ influx through synaptic NMDA receptors (NMDA-Rs) triggers a variety of adaptive
cellular processes. To probe NMDA-R-mediated [Ca 2+ ] signaling, we used two-photon …
cellular processes. To probe NMDA-R-mediated [Ca 2+ ] signaling, we used two-photon …
Supersensitive Ras activation in dendrites and spines revealed by two-photon fluorescence lifetime imaging
To understand the biochemical signals regulated by neural activity, it is necessary to measure
protein-protein interactions and enzymatic activity in neuronal microcompartments such as …
protein-protein interactions and enzymatic activity in neuronal microcompartments such as …
[PDF][PDF] Differential modification of Ras proteins by ubiquitination
Ras proteins are essential components of signal transduction pathways that control cell
proliferation, differentiation, and survival. It is well recognized that the functional versatility of Ras …
proliferation, differentiation, and survival. It is well recognized that the functional versatility of Ras …
[PDF][PDF] Price dynamics and liquidity of exchange-traded funds
A Madhavan, A Sobczyk - Journal of Investment …, 2016 - centerforfinancialstability.org
Exchange-traded funds (ETFs) have grown substantially in diversity, market significance,
and size in recent years. As a consequence, there is increased interest by practitioners in the …
and size in recent years. As a consequence, there is increased interest by practitioners in the …
Nonlinear [Ca2+] signaling in dendrites and spines caused by activity-dependent depression of Ca2+ extrusion
Spine Ca 2+ triggers the induction of synaptic plasticity and other adaptive neuronal responses.
The amplitude and time course of Ca 2+ signals specify the activation of the signaling …
The amplitude and time course of Ca 2+ signals specify the activation of the signaling …
[HTML][HTML] Activity-dependent plasticity of the NMDA-receptor fractional Ca2+ current
Ca 2+ influx through NMDA receptors (NMDA-Rs) triggers synaptic plasticity, gene transcription,
and cytotoxicity, but little is known about the regulation of NMDA-Rs themselves. We …
and cytotoxicity, but little is known about the regulation of NMDA-Rs themselves. We …
Toward ESG alpha: Analyzing ESG exposures through a factor lens
Using data on 1,312 active US equity mutual funds with $3.9 trillion in assets under management,
we analyzed the link between funds’ bottom-up, holdings-based environmental, social, …
we analyzed the link between funds’ bottom-up, holdings-based environmental, social, …
Estimating time-varying factor exposures (corrected october 2017)
We develop a methodology to estimate dynamic factor loadings using cross-sectional risk
characteristics. Applying it to a dataset of US-domiciled mutual funds, we distinguish the …
characteristics. Applying it to a dataset of US-domiciled mutual funds, we distinguish the …
On the factor implications of sustainable investing in fixed-income active funds
A Madhavan, A Sobczyk - The Journal of Portfolio Management, 2020 - pm-research.com
Interest in sustainable investing in fixed income has grown tremendously. A natural question
concerns how environmental, social, and governance (ESG) attributes affect expected …
concerns how environmental, social, and governance (ESG) attributes affect expected …