User profiles for Aleksander Sobczyk

Aleksander Sobczyk

SVP, Two Sigma Investments LP
Verified email at twosigma.com
Cited by 2479

Channelrhodopsin-2–assisted circuit mapping of long-range callosal projections

L Petreanu, D Huber, A Sobczyk, K Svoboda - Nature neuroscience, 2007 - nature.com
The functions of cortical areas depend on their inputs and outputs, but the detailed circuits
made by long-range projections are unknown. We show that the light-gated channel …

NMDA receptor subunit-dependent [Ca2+] signaling in individual hippocampal dendritic spines

A Sobczyk, V Scheuss, K Svoboda - Journal of Neuroscience, 2005 - Soc Neuroscience
Ca 2+ influx through synaptic NMDA receptors (NMDA-Rs) triggers a variety of adaptive
cellular processes. To probe NMDA-R-mediated [Ca 2+ ] signaling, we used two-photon …

Supersensitive Ras activation in dendrites and spines revealed by two-photon fluorescence lifetime imaging

R Yasuda, CD Harvey, H Zhong, A Sobczyk… - Nature …, 2006 - nature.com
To understand the biochemical signals regulated by neural activity, it is necessary to measure
protein-protein interactions and enzymatic activity in neuronal microcompartments such as …

[PDF][PDF] Differential modification of Ras proteins by ubiquitination

N Jura, E Scotto-Lavino, A Sobczyk, D Bar-Sagi - Molecular cell, 2006 - cell.com
Ras proteins are essential components of signal transduction pathways that control cell
proliferation, differentiation, and survival. It is well recognized that the functional versatility of Ras …

[PDF][PDF] Price dynamics and liquidity of exchange-traded funds

A Madhavan, A Sobczyk - Journal of Investment …, 2016 - centerforfinancialstability.org
Exchange-traded funds (ETFs) have grown substantially in diversity, market significance,
and size in recent years. As a consequence, there is increased interest by practitioners in the …

Nonlinear [Ca2+] signaling in dendrites and spines caused by activity-dependent depression of Ca2+ extrusion

V Scheuss, R Yasuda, A Sobczyk… - Journal of …, 2006 - Soc Neuroscience
Spine Ca 2+ triggers the induction of synaptic plasticity and other adaptive neuronal responses.
The amplitude and time course of Ca 2+ signals specify the activation of the signaling …

[HTML][HTML] Activity-dependent plasticity of the NMDA-receptor fractional Ca2+ current

A Sobczyk, K Svoboda - Neuron, 2007 - cell.com
Ca 2+ influx through NMDA receptors (NMDA-Rs) triggers synaptic plasticity, gene transcription,
and cytotoxicity, but little is known about the regulation of NMDA-Rs themselves. We …

Toward ESG alpha: Analyzing ESG exposures through a factor lens

A Madhavan, A Sobczyk, A Ang - Financial Analysts Journal, 2021 - Taylor & Francis
Using data on 1,312 active US equity mutual funds with $3.9 trillion in assets under management,
we analyzed the link between funds’ bottom-up, holdings-based environmental, social, …

Estimating time-varying factor exposures (corrected october 2017)

A Ang, A Madhavan, A Sobczyk - Financial Analysts Journal, 2017 - Taylor & Francis
We develop a methodology to estimate dynamic factor loadings using cross-sectional risk
characteristics. Applying it to a dataset of US-domiciled mutual funds, we distinguish the …

On the factor implications of sustainable investing in fixed-income active funds

A Madhavan, A Sobczyk - The Journal of Portfolio Management, 2020 - pm-research.com
Interest in sustainable investing in fixed income has grown tremendously. A natural question
concerns how environmental, social, and governance (ESG) attributes affect expected …