The mammalian brain consists of millions to billions of cells that are organized into many cell
types with specific spatial distribution patterns and structural and functional properties 1 , 2 …

Many neurodegenerative diseases cause degeneration of specific types of neurons. For
example, glaucoma leads to death of retinal ganglion cells, leaving other neurons intact. …

We previously used single-cell transcriptomic analysis to characterize human fetal retinal
development and assessed the degree to which retinal organoids recapitulate normal …

Müller glia (MG) serve as sources for retinal regeneration in non-mammalian vertebrates. We
find that this process can be induced in mouse MG, after injury, by transgenic expression of …

The innate immune system plays key roles in tissue regeneration. For example, microglia
promote neurogenesis in Müller glia in birds and fish after injury. Although mammalian retina …

Regenerative neuroscience aims to stimulate endogenous repair in the nervous system to
replace neurons lost from degenerative diseases. Recently, we reported that overexpressing …

Müller glial cells (MG) generate retinal progenitor (RPC)-like cells after injury in non-mammalian
species, although this does not occur in the mammalian retina. Studies have profiled …

Diseases and damage to the retina lead to losses in retinal neurons and eventual visual
impairment. Although the mammalian retina has no inherent regenerative capabilities, fish have …

Retinal degeneration in mammals causes permanent loss of vision, due to an inability to
regenerate naturally. Some non-mammalian vertebrates show robust regeneration, via Muller …

Retinal degeneration is a common cause of irreversible blindness and is caused by the
death of retinal light-sensitive neurons called photoreceptors. At the onset of degeneration, …