Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling
INTRODUCTION More than 50% of patients treated with chimeric antigen receptor (CAR)–T
cells for B cell malignancies develop progressive disease after CAR therapy, and these …
cells for B cell malignancies develop progressive disease after CAR therapy, and these …
Convergence of Energy and Financial Markets
P Anbunathan, P Roy, R Anantharam - The Journal of Trading, 2006 - pm-research.com
The energy market has been characterized in recent years by an enormous amount of volatility
and record high prices. One of the significant trends that we see emerging out from this …
and record high prices. One of the significant trends that we see emerging out from this …
Experimental investigation of sliding wear behaviour of boron carbide and mica reinforced aluminium alloy hybrid metal matrix composites using Box-Behnken design
In this work, wear performance of hybrid aluminium metal matrix composite (AMMC) was
studied owing to the influence of mica addition on dry sliding. Technique of Stir casting is used …
studied owing to the influence of mica addition on dry sliding. Technique of Stir casting is used …
Evaluation of mechanical properties of tea dust filler reinforced polymer composite
KK Theja, G Bharathiraja, VS Murugan… - Materials Today …, 2023 - Elsevier
Nowadays, environmental sustainability is the responsible of engineering community for
which the usage of waste or recycling is essential towards ecological sustainability, for which …
which the usage of waste or recycling is essential towards ecological sustainability, for which …
Enhanced T cell effector activity by targeting the Mediator kinase module
T cells are the major arm of the immune system responsible for controlling and regressing
cancers. To identify genes limiting T cell function, we conducted genome-wide CRISPR …
cancers. To identify genes limiting T cell function, we conducted genome-wide CRISPR …
Next-generation CAR T-cell therapies
RM Young, NW Engel, U Uslu, N Wellhausen, CH June - Cancer discovery, 2022 - AACR
Next-Generation CAR T-cell Therapies | Cancer Discovery | American Association for Cancer
Research Skip to Main Content Advertisement Umbrella Alt Text Umbrella Alt Text Close …
Research Skip to Main Content Advertisement Umbrella Alt Text Umbrella Alt Text Close …
Engineered skin bacteria induce antitumor T cell responses against melanoma
YE Chen, D Bousbaine, A Veinbachs, K Atabakhsh… - Science, 2023 - science.org
Certain bacterial colonists induce a highly specific T cell response. A hallmark of this encounter
is that adaptive immunity develops preemptively, in the absence of an infection. However…
is that adaptive immunity develops preemptively, in the absence of an infection. However…
In vitro modeling of CD8+ T cell exhaustion enables CRISPR screening to reveal a role for BHLHE40
Identifying molecular mechanisms of exhausted CD8 T cells (T ex ) is a key goal of improving
immunotherapy of cancer and other diseases. However, high-throughput interrogation of in …
immunotherapy of cancer and other diseases. However, high-throughput interrogation of in …
[PDF][PDF] Deletion of the inhibitory co-receptor CTLA-4 enhances and invigorates chimeric antigen receptor T cells
Chimeric antigen receptor (CAR) T cell therapy targeting CD19 has achieved tremendous
success treating B cell malignancies; however, some patients fail to respond due to poor …
success treating B cell malignancies; however, some patients fail to respond due to poor …
BLIMP1 and NR4A3 transcription factors reciprocally regulate antitumor CAR T cell stemness and exhaustion
Chimeric antigen receptor (CAR) T cells have not induced meaningful clinical responses in
solid tumors. Loss of T cell stemness, poor expansion capacity, and exhaustion during …
solid tumors. Loss of T cell stemness, poor expansion capacity, and exhaustion during …