Strain typing of microbial pathogens has two major aims: (i) to index genetic microvariation
for use in outbreak investigations and (ii) to index genetic macrovariation for use in …

Although isoniazid (isonicotinic acid hydrazide, INH) is widely used for the treatment of
tuberculosis, its molecular target has remained elusive. In response to INH treatment, saturated …

Isoniazid (INH) is a central component of drug regimens used worldwide to treat tuberculosis.
Previous studies have identified resistance-associated mutations in katG, inhA, kasA, ndh, …

Protective immunity against pulmonary tuberculosis (TB) is characterized by the formation in
the lungs of granulomas consisting of macrophages and activated T cells producing tumor …

Airline planning consists of several problems that are currently solved separately. We
address a partial integration of schedule planning, aircraft routing, and crew scheduling. In …

Ethambutol (EMB) is a central component of drug regimens used worldwide for the
treatment of tuberculosis. To gain insight into the molecular genetic basis of EMB resistance, …

The airline crew scheduling problem is the problem of assigning crew itineraries to flights.
We develop a new approach for solving the problem that is based on enumerating hundreds …

The mercury (,) photosensitized internal cycloaddition reactions of 1, 4-pentadiene, 2-methyl-l,
4-pentadiene, 2, 4-dimethyl-l, 4-pentadiene, 1, 5-hexadiene, 2-methyl-l, 5-hexadiene, 1, 5-…

To obtain a general framework for understanding selection of antibiotic-resistant mutants,
allelic diversity was examined with about 600 fluoroquinolone-resistant mutants of …

Thirty-seven multidrug-resistant and 13 pan-susceptible isolates of Mycobacterium
tuberculosis were analysed for the diversity of genotypes associated with known drug-resistance …